Dimethylbenzanthracene tumorigenesis and aryl hydrocarbon hydroxylase in mouse skin: inhibition by 7,8-benzoflavone

Science. 1970 Oct 9;170(3954):169-71. doi: 10.1126/science.170.3954.169.

Abstract

Mouse skin contains aryl hydrocarbon hydroxylase which is highly inducible. The enzyme system is inhibited when 7,8-benzoflavone is added to homogenates of skin epidermis. 7,8-Benzoflavone also inhibits mouse skin tumorigenesis caused by repeated treatment with 9,10-dimethylbenzanthracene or by a single treatment with this chemical followed by weekly treatment with croton oil. These findings suggest that this enzyme system may be responsible for the activation of 9,10-dimethylbenzanthracene to its carcinogenic form.

MeSH terms

  • Animals
  • Benz(a)Anthracenes / antagonists & inhibitors*
  • Cell Transformation, Neoplastic
  • Croton Oil
  • Flavonoids / pharmacology*
  • Mice
  • Mixed Function Oxygenases / antagonists & inhibitors*
  • Naphthalenes / metabolism
  • Neoplasms, Experimental / chemically induced
  • Skin / enzymology
  • Skin Neoplasms / chemically induced*
  • Skin Neoplasms / drug therapy

Substances

  • Benz(a)Anthracenes
  • Flavonoids
  • Naphthalenes
  • Croton Oil
  • Mixed Function Oxygenases