Ophthalmoplegia, ataxia and hyporeflexia (Fisher's syndrome). With a midbrain lesion demonstrated by CT scanning

Eur Neurol. 1979;18(6):361-6. doi: 10.1159/000115105.


This report concerns a patient with ophthalmoplegia, ataxia and hyporeflexia (Fisher's syndrome) with a lesion in the midbrain tegmentum demonstrated by computerized-tomography (CT) scanning. Spontaneous recovery was almost complete 1 month after the onset. Based upon its strategic location, it is suggested that the lesion can explain the findings in the patient. The CT finding, if confirmed, will necessitate a reconsideration of our current pathogenetic views about Landry-Guillain-Barré syndrome in general and Fisher's syndrome in particular.

Publication types

  • Case Reports

MeSH terms

  • Ataxia / etiology*
  • Brain Diseases / physiopathology
  • Child
  • Female
  • Humans
  • Mesencephalon / pathology
  • Ophthalmoplegia / etiology*
  • Polyradiculoneuropathy / diagnostic imaging*
  • Reflex, Abnormal / etiology*
  • Tegmentum Mesencephali / diagnostic imaging*
  • Tomography, X-Ray Computed*