Chlorine dioxide metabolism in rat

J Environ Pathol Toxicol. 1979 Dec;3(1-2):421-30.


Chlorine dioxide (ClO2) is under consideration as an alternative to chlorination as a disinfectant for public water supplies. A new assay was developed to qualitatively and quantitatively measure the metabolites of 36ClO2 in water and biological fluids. Studies in the rat indicated that the metabolites of ClO2 were Cl-, ClO-2, and ClO-b. At maximum absorption the percentage of ClO; formed in plasma from an initial oral dose of 10 mg/l 36ClO, was higher than from a 100 mg/l dose. The 36Cl concentration in washed packed cells indicated that 36Cl readily exchanges with chloride of saline.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Chlorates / analysis
  • Chlorine / blood
  • Chlorine / metabolism*
  • Chlorine / urine
  • Chlorine Compounds*
  • Disinfectants
  • Male
  • Oxides / blood
  • Oxides / metabolism*
  • Oxides / urine
  • Oxygen / analysis
  • Rats
  • Water Supply


  • Chlorates
  • Chlorine Compounds
  • Disinfectants
  • Oxides
  • Chlorine
  • chlorine dioxide
  • Oxygen