Protection from the embryopathic effects of 7-hydroxymethyl-12-methylbenz(a)anthracene by 2-methyl-1,2-bis-(3-pyridyl)1-propanone(metopirone, Ciba) and beta-diethylaminoethyldiphenyl-n-propyl acetate (SKF 525-A)

Br J Cancer. 1970 Sep;24(3):548-53. doi: 10.1038/bjc.1970.66.

Abstract

Pretreatment with Metopirone (40 mg.) or SKF 525-A (2 mg./100 g. maternal body weight) protected aganist the embryotoxic and teratogenic actions of7-OHM-12-MBA) (2.5 mg/100 g. maternal body weight) in the Sprague-Dawley rat. At the doses administered SKF-525-A was a more efficient protector than Metopirone. The adrenocorticolytic actions of 7-OHM-12-MBA in the maternal adrenal glands were also prevented by these compounds and a close correlation existed between the degree of protection of the maternal adrenals and of the foetuses. It is suggested that the ultimate embryopathic substance is a metabolite of 7-OHM-12-MBA.

MeSH terms

  • Abnormalities, Drug-Induced
  • Adrenal Glands / drug effects
  • Animals
  • Benz(a)Anthracenes / antagonists & inhibitors*
  • Embryo, Mammalian / drug effects*
  • Female
  • Metyrapone / pharmacology*
  • Organ Size
  • Placenta / drug effects
  • Pregnancy
  • Proadifen / pharmacology*
  • Rats

Substances

  • Benz(a)Anthracenes
  • Proadifen
  • Metyrapone