Isoniazid pharmacokinetics in kwashiorkor

S Afr Med J. 1979 Aug 25;56(8):299-300.


Isoniazid plasma half-life and clearance rates were studied in children with kwashiorkor before and after nutritional rehabilitation. Isoniazid half-life rates fell and clearance increased with nutritional rehabilitation. The changes documented in this report are not an indication that isoniazid therapy should be altered in malnourished children, but may indicate that this should be done in malnourished adults.

MeSH terms

  • Half-Life
  • Humans
  • Infant
  • Isoniazid / blood
  • Isoniazid / metabolism*
  • Kwashiorkor / metabolism*
  • Time Factors
  • Tuberculin Test


  • Isoniazid