Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication

Nature. 1979 Jan 18;277(5693):192-8. doi: 10.1038/277192a0.


A fragment of HeLa cell mitochondrial DNA containing the origin of replicaton has been sequenced. The precise position of the origin in this sequence has been identified by determining the nucleotide order in the 5'-end proximal portion of the heavy strand initiation fragment (7S DNA), and by aligning the two sequences.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • DNA Replication*
  • DNA, Mitochondrial / genetics*
  • HeLa Cells
  • Humans
  • Hydrogen Bonding
  • Mitochondria / physiology*
  • Molecular Weight
  • Nucleic Acid Conformation


  • DNA, Mitochondrial

Associated data

  • GENBANK/J01415
  • GENBANK/M12548