A role for brown adipose tissue in diet-induced thermogenesis

Nature. 1979 Sep 6;281(5726):31-5. doi: 10.1038/281031a0.


Measurement of energy balance during voluntary overeating in rats unequivocally establishes the quantitative importance of diet-induced thermogenesis in energy balance. Like cold-induced thermogenesis, this form of heat production involves changes in the activity of the sympathetic nervous system and brown adipose tissue which suggest that this tissue may determine metabolic efficiency and resistance to obesity.

Publication types

  • Comparative Study

MeSH terms

  • Adipose Tissue, Brown / physiology*
  • Animals
  • Body Temperature Regulation*
  • Diet*
  • Disease Models, Animal
  • Energy Metabolism
  • Humans
  • Lipid Mobilization
  • Male
  • Norepinephrine / pharmacology
  • Obesity / metabolism
  • Oxygen Consumption / drug effects
  • Rats
  • Sympathetic Nervous System / physiology


  • Norepinephrine