Enhanced efflux of actinomycin D, vincristine, and vinblastine in adriamycin-resistant subline of P388 leukemia

Cancer Lett. 1979 Dec;8(2):111-5. doi: 10.1016/0304-3835(79)90003-x.


In vitro cross-resistance of adriamycin-resistant subline of P388 leukemia to non-anthracycline agents-actinomycin D, vincristine and vinblastine was elucidated. Decreased uptake of these 3 drugs was observed with the resistant cells. In addition, 2,4-dinitrophenol, a metabolic inhibitor, greatly enhanced the uptake of these drugs by the sensitive and resistant cell lines, particularly by the latter, abolishing a difference in drug uptake between the 2 which was observed under the normal condition. These results suggest that adriamycin-resistant cells are endowed with an enhanced capacity for outward transport of not only anthracycline antibiotics, but chemically and pharmacologically dissimilar agents such as the aforementioned agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Dactinomycin / metabolism*
  • Doxorubicin / pharmacology*
  • Drug Resistance
  • Leukemia P388 / drug therapy
  • Leukemia P388 / metabolism*
  • Leukemia, Experimental / metabolism*
  • Mice
  • Vinblastine / metabolism*
  • Vincristine / metabolism*


  • Dactinomycin
  • Vincristine
  • Vinblastine
  • Doxorubicin