Stress-induced modulation of the immune response

Science. 1977 Apr 15;196(4287):307-8. doi: 10.1126/science.557841.

Abstract

After mice were exposed to a daily auditory stressor for varying lengths of time, the responses of their splenic lymphoid cells in vitro were assessed. Both the blastogenic activity of concanavalin A or lipopolysaccharide and the ability of immune lymphocytes to lyse P815 target cells showed the same patterns of immunosuppression and enhancement.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cytotoxicity Tests, Immunologic
  • Humans
  • Hydrocortisone / blood
  • Immunity, Cellular*
  • Immunosuppression Therapy
  • Lymphocyte Activation
  • Lymphocytes / immunology*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Noise
  • Spleen / immunology
  • Stress, Physiological / blood
  • Stress, Psychological / physiology*
  • Time Factors

Substances

  • Hydrocortisone