Azoospermia in dogs induced by injection of sclerosing agents into the caudae of the epididymides

Am J Vet Res. 1977 Jun;38(6):831-8.

Abstract

Injections of sclerosing agents into the caudae of the epididymides of adult and prepubertal dogs induced a long-lasting and probably irreversible azoospermia. The technique is easy to do and inexpensive, does not seem to cause undesirable side effects, and appears suitable for large-scale sterilization programs in male dogs.

PIP: Azoospermia in dogs induced by injection of sclerosing agents into the caudae of the epididymides was investigated. Treatment with formalin induced temporary azoospermia or oligospermia in all treated dogs; testicular diameter increased significantly (p less than .05) on Days 5 and 7 after treatment. The 2 dogs teated with 1.5% chlorhexidine gluconate in 50% DMSO became azoospermic for the duration of the study. Treatment with a 3.3% solution of formalin in .05 M phosphate-buffered saline solution induced temporary azoospermia or oligospermia. The technqiue described is effective, easy to apply, inexpensive, does not seem to cause undesirable side effects, and appears suitable for large-scale sterilization in male dogs.

MeSH terms

  • Animals
  • Chlorhexidine / pharmacology
  • Dimethyl Sulfoxide / pharmacology
  • Dogs / physiology*
  • Ejaculation
  • Epididymis / drug effects*
  • Epididymis / pathology
  • Formaldehyde / pharmacology
  • Male
  • Sclerosing Solutions / pharmacology*
  • Semen / cytology
  • Spermatozoa / cytology
  • Sterilization, Reproductive / methods
  • Sterilization, Reproductive / veterinary*
  • Testis / anatomy & histology

Substances

  • Sclerosing Solutions
  • Formaldehyde
  • Chlorhexidine
  • Dimethyl Sulfoxide