Plant anticancer agents III: Isolation of indole and bisindole alkaloids from Tabernaemontana holstii roots

J Pharm Sci. 1977 Aug;66(8):1135-8. doi: 10.1002/jps.2600660821.


Certain active antileukemic and cytotoxic fractions prepared from Tabernaemontana holstii roots were investigated, resulting in the isolation of the known indole alkaloids conoduramine, conodurine, coronaridine, gabunine, 19-oxocoronaridine, pericyclivine, perivine, and vobasine. Two new alkaloids were assigned the structures 19-oxoconodurine and 19-(2-oxopropyl)conodurine. Both gabunine and 19-(2-oxopropyl)conodurine showed significant inhibitory activity against P-388 cell culture. All of the alkaloids are reported for the first time from T. holstii; conodurine, conoduramine, gabunine, perivine, and pericyclivine are reported for the first time from any Tabernaemontana species.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Alkaloids / therapeutic use
  • Animals
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Cells, Cultured
  • Chromatography, Gel
  • In Vitro Techniques
  • Indoles / isolation & purification
  • Indoles / pharmacology
  • Indoles / therapeutic use
  • Leukemia, Experimental / drug therapy
  • Neoplasms, Experimental / drug therapy
  • Phytotherapy
  • Plants, Medicinal / analysis*


  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Indoles