The preferential cytotoxicity of reovirus for certain transformed cell lines

Arch Virol. 1977;54(4):307-15. doi: 10.1007/BF01314776.

Abstract

The susceptibility of a variety of cell lines of different mammalian origin to cytotoxic (CT) induction by either ultraviolet light-irradiated reovirus type 2 (UVR2) or viable reovirus type 2 plus the protein synthesis inhibitor, cycloheximide, was examined. The following groups of cells were found to be susceptible to CT-induction: certain tumor cells and spontaneously transformed cell lines of human origin and certain virally and spontaneously transformed cell lines of murine origin. The following groups of cells were found to be resistant: normal human diploid cell lines, primary and continuous cell cultures of subhuman primates, primary mouse cells, normal rat kidney cells and baby hamster kidney cells. Susceptibility to CT-induction could not be related to the adsorption of virus to cells, nor to the capacity of the cell to support virus replication.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Line
  • Cell Transformation, Neoplastic
  • Cricetinae
  • Cycloheximide / pharmacology
  • Cytopathogenic Effect, Viral*
  • Humans
  • Mice
  • Rabbits
  • Rats
  • Reoviridae / drug effects
  • Reoviridae / growth & development*
  • Reoviridae / radiation effects
  • Species Specificity
  • Ultraviolet Rays

Substances

  • Cycloheximide