A physiologic analysis of cardiopulmonary responses to ketamine anesthesia in noncardiac patients

Anesth Analg. Nov-Dec 1977;56(6):813-6.


In 16 adult patients, IV ketamine, 2.2 mg/kg body weight, did not produce dramatic effects on left heart function or systemic circulation. Minute O2 consumption and O2 delivery were stable. An appreciable elevation in pulmonary vascular resistance occurred which secondarily increased right heart work. Total intrapulmonary shunt initially increased; however, the effect was short lived and did not cause clinical alterations in PaO2. The authors conclude that physiologic alterations associated with ketamine are more pronounced on the pulmonary than on the systemic vascular bed, and to the right rather than to the left side of the heart.

MeSH terms

  • Adult
  • Anesthesia, General*
  • Blood Pressure / drug effects
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • Humans
  • Ketamine / pharmacology*
  • Ketamine / therapeutic use
  • Oxygen Consumption / drug effects
  • Pulmonary Circulation / drug effects
  • Respiration / drug effects*
  • Vascular Resistance / drug effects


  • Ketamine