Anticonvulsant-induced osteomalacia

Age Ageing. 1977 Nov;6(4):228-31. doi: 10.1093/ageing/6.4.228.


Four cases of osteomalacia associated with the long term consumption of phenytoin (Dilantin) were admitted to a geriatric unit in a two-month period. No other cause for their disease was found. The diagnosis was made on biochemical data and no bone biopsy was obtained. Radiographic evidence was found in two cases only.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Chick Embryo
  • Dose-Response Relationship, Drug
  • Female
  • Fractures, Bone / etiology
  • Humans
  • Osteomalacia / chemically induced*
  • Osteomalacia / complications
  • Phenytoin / administration & dosage
  • Phenytoin / adverse effects*


  • Phenytoin