Immunosuppressive activity of 3-acetyl-5-(4-fluorobenzylidene)-4-hydroxy-2-oxo-2:5-dihydrothiophen (I.C.I. 47,776)

Abstract

A novel type of immunosuppressive agent, 3-acetyl-5-(4-fluorobenzylidene)4-hydroxy-2-oxo-2:5-dihydrothiophen (I.C.I. 47,776) inhibits the production of antibodies in rats when given orally. The treatment is still effective when commenced several days after immunization. No effect has been demontrated in mice or in guinea-pigs.