[Oleum hippophaë, a stabilizer of biological membranes]

Farmakol Toksikol. Jan-Feb 1978;41(1):105-9.
[Article in Russian]

Abstract

Toxic lesion of the liver was reproduced in albino rats by way of a separate and combined intragastric administration of a 20 per cent ethanol (in doses of 0.65 ml/100 g of mass) and of a 20 per cent CCl4 oil solution (in amounts of 0.3 ml/100 g of mass), thrice in a week for 3 months. Subject to investigation were the intensity of the lipids peroxidation with reference to the diene conjugates level in the liver tissue and peroxide resistance of the peripheral blood erythrocytes, P-450 cytochromes in the supernatant fluid after precipitation of the nuclei and mitochondria, total liver protein and subcellular structures, water-soluble liver protein. The activity of the P-450 cytochrome and the content of the total and water-soluble liver protein were found to change antibathmically to the lipids oxidation intensity, especially in animals receiving both poisons. Oleum hippopheae causes a well-marked anabolic effect which manifests itself in an increased proportion of tissular and serumal proteins. It lowers the free radical oxidation of the lipids, protects the cytochromes P-450 against damage. The mechanisms of the results, obtained are discussed.

Publication types

  • English Abstract

MeSH terms

  • Alcoholism / drug therapy
  • Alcoholism / metabolism
  • Animals
  • Antioxidants*
  • Carbon Tetrachloride Poisoning / drug therapy
  • Carbon Tetrachloride Poisoning / metabolism
  • Cell Membrane / drug effects*
  • Chronic Disease
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Evaluation, Preclinical
  • Humans
  • Lipid Metabolism
  • Liver / drug effects
  • Liver / metabolism
  • Oils, Volatile / therapeutic use*
  • Oxidation-Reduction / drug effects
  • Peroxides / metabolism
  • Plants, Medicinal*
  • Proteins / metabolism
  • Rats

Substances

  • Antioxidants
  • Oils, Volatile
  • Peroxides
  • Proteins
  • Cytochrome P-450 Enzyme System