Cefamandole---a review of chemistry and microbiology

J Infect Dis. 1978 May;137 Suppl:S10-S16. doi: 10.1093/infdis/137.supplement.s10.

Abstract

The discovery of cephalosporin C and its conversion to 7-aminocephalosporanic acid (7-ACA) are reviewed. The syntheses of cefamandole and three other injectable cephalosporins from 7-ACA are described, and the antibiotic properties of the four drugs are compared. The microbiological potency of cefamandole is comparable to that of cephalothin, cephaloridine, and cefazolin against gram-positive organisms. Cefamandole is the most potent of the four compounds against gram-negative bacteria. In addition, cefamandole inhibits Enterobacter and strains of indole-positive Proteus which have been traditionally resistant to the cephalosporins. For pharmaceutical reasons cefamandole nafate was chosen for the clinical formulation of the antibiotic.

MeSH terms

  • Acremonium / analysis
  • Cefamandole* / pharmacology
  • Cephalosporins* / chemical synthesis
  • Cephalosporins* / isolation & purification
  • Cephalosporins* / pharmacology
  • Chemical Phenomena
  • Chemistry
  • Enterobacter / drug effects
  • Haemophilus / drug effects
  • Proteus / drug effects

Substances

  • Cephalosporins
  • Cefamandole