Metabolites of Dactylaria lutea. The structures of dactylariol and the antiprotozoal antibiotic dactylarin

J Antibiot (Tokyo). 1978 Apr;31(4):324-9. doi: 10.7164/antibiotics.31.324.

Abstract

The metabolites of the predacious fungus Dactylaria lutea ROUTIEN include the anthraquinone macrosporin (2) and three hydroxylated 1,2,3,4-tetrahydro derivatives of this anthraquinone, altersolanol A (5), altersolanol B (4) and dactylariol (6). The structure and relative configuration of dactylariol are established from spectroscopic studies, and its absolute configuration is proposed as 1R, 2R, 3R by virtue of its co-occurrence with altersolanol B. Dactylarin, suggested by other authors to have the structure (1), is shown to be identical with altersolanol B (4).

MeSH terms

  • Anthraquinones / biosynthesis*
  • Anti-Bacterial Agents / biosynthesis*
  • Antiprotozoal Agents / metabolism*
  • Chemical Phenomena
  • Chemistry
  • Mitosporic Fungi / metabolism*
  • Molecular Conformation

Substances

  • Anthraquinones
  • Anti-Bacterial Agents
  • Antiprotozoal Agents