The central effects of a novel dopamine agonist

Eur J Pharmacol. 1978 Aug 15;50(4):419-30. doi: 10.1016/0014-2999(78)90148-6.


A new peripheral dopamine agonist which causes dopaminergic renal vasodilation, was tested for central dopaminergic activity. SK & F 38393 stimulated the dopamine-sensitive adenylate cyclase in homogenates of rat caudate, as a partial agonist, and caused contralateral rotation in rats with unilateral 6-OHDA lesions of substantia nigra. Rotation was shown to be due to a direct effect on supersensitive dopamine receptors. Stimulation of cAMP formation and rotation were blocked by dopamine antagonists. In contrast to other dopamine agonists, SK & F 38393 did not cause stereotypy, emesis or inhibition of prolactin release, nor did SK & F 38393 affect dopamine turnover. The results suggest that SK & F 38393 may selectively stimulate supersensitive central dopamine receptors in vivo or may activate only a certain subclass of dopamine receptors including the receptor in the renal vasculature and the adenylate cyclase coupled postsynaptic receptor in the caudate.

MeSH terms

  • Adenylyl Cyclases / metabolism
  • Animals
  • Benzazepines / pharmacology*
  • Dogs
  • Dopamine / metabolism
  • Dopamine / physiology*
  • Female
  • Humans
  • Male
  • Prolactin / blood
  • Rats
  • Stereotyped Behavior / drug effects
  • Substantia Nigra / physiology
  • Vomiting / chemically induced


  • Benzazepines
  • Prolactin
  • Adenylyl Cyclases
  • Dopamine