Abstract
The feeding of ethanol increased significantly the activities of hepatic pentobarbital and benzpyrene hydroxylases in rats, and, in human volunteers, doubled pentobarbital hydroxylase activity. In vitro ethanol inhibited aniline, pentobarbital, and benzpyrene hydroxylases. These data may explain, at least in part, the increased tolerance of alcoholics to sedatives when sober, and the enhanced sensitivity to sedatives when inebriated.
MeSH terms
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Alcoholism
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Aniline Compounds / metabolism*
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Animals
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Barbiturates / pharmacology
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Benzopyrenes / metabolism*
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Depression, Chemical
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Drug Tolerance
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Enzyme Induction*
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Ethanol / pharmacology*
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Female
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Humans
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Liver / cytology
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Liver / drug effects
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Liver / enzymology*
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Male
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Microsomes / drug effects
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Microsomes / enzymology*
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Mixed Function Oxygenases / antagonists & inhibitors
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Mixed Function Oxygenases / biosynthesis*
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Pentobarbital / metabolism*
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Rats
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Stimulation, Chemical
Substances
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Aniline Compounds
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Barbiturates
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Benzopyrenes
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Ethanol
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Mixed Function Oxygenases
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Pentobarbital