Defects of the central nervous system in Finland: III. Disease and drugs in pregnancy

Early Hum Dev. 1978 Jul;2(2):147-62. doi: 10.1016/0378-3782(78)90007-5.


The matched pair system of the Finnish Register of Congenital Malformations was used to search for association between defects of the central nervous system (CNS), and maternal diseases and/or drug consumption during pregnancy. The study material consisted of 710 cases with CNS defects and their controls. Significant associations were found for the following conditions: influenza, threatened abortion, depressive state, toxemia of pregnancy, diabetic mothers, and for the consumption of the following drugs: salicylates, pyrazolones/anilines, euphoristic analgesics, sympathomimetics, barbiturates, and cough medicines. 259 cases with polydactyly and their controls were also compared, with a view to demonstrating what biases might be introduced by the case-control method. After utilizing the possibilities of this design for examining the above mentioned significant associations, the factors to be seriously considered were reduced to the following ones: influenza, depressive state, toxemia of pregnancy, diabetic mothers and cough medicines.

MeSH terms

  • Abnormalities, Drug-Induced*
  • Abnormalities, Multiple / etiology
  • Antitussive Agents / adverse effects
  • Central Nervous System / abnormalities*
  • Congenital Abnormalities / etiology*
  • Depression / complications
  • Female
  • Fingers / abnormalities
  • Finland
  • Humans
  • Influenza, Human / complications
  • Pre-Eclampsia / complications
  • Pregnancy
  • Pregnancy Complications*
  • Pregnancy Complications, Infectious
  • Pregnancy Trimester, First
  • Pregnancy in Diabetics / complications


  • Antitussive Agents