The prevention by creatinol O-phosphate of myocardial lesions evoked by isoprenaline

Arch Int Pharmacodyn Ther. 1979 Feb;237(2):288-97.

Abstract

Isoprenaline 30 mg/kg has been injected subcutaneously in rats pretreated or not with Creatinol O-phosphate (200 mg/kg intraperitoneously). Isoprenaline-induced cardionecrosis and the associated alterations of the ionic composition of the heart were reduced when Creatinol O-phosphate was injected 4 hr before isoprenaline.

MeSH terms

  • Animals
  • Cardiomyopathies / chemically induced
  • Cardiomyopathies / pathology
  • Cardiomyopathies / prevention & control*
  • Creatine / analogs & derivatives*
  • Creatine / therapeutic use*
  • Female
  • Ions / metabolism
  • Isoproterenol / antagonists & inhibitors*
  • Myocardium / pathology
  • Necrosis
  • Rats
  • Time Factors

Substances

  • Ions
  • Isoproterenol
  • Creatine