Genetic factors in canine narcolepsy

Sleep. 1979 Summer;1(4):413-21. doi: 10.1093/sleep/1.4.413.

Abstract

The mating of narcopleptic Doberman pinschers yielded 30 puppies in five litters, all of which developed the disease between 1 and 4 months of age. Pedigrees of the Doberman probands are indicative of an autosomal recessive mode of transmission. An analysis of the pedigree of five affected Labrador retriever littermates suggests a similar mode of transmission. Crosses of affected dogs in two other breeds (miniature poodles and beagles) have resulted in all-unaffected F1 generations, thus allowing rejection of the simplest genetic hypothesis of a fully penetrant autosomal or sex-linked dominant or recessive gene.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Animals
  • Dogs
  • Female
  • Humans
  • Male
  • Narcolepsy / genetics*
  • Pedigree
  • Pregnancy