Removal of phenytoin by hemodialysis in uremic patients

JAMA. 1977 Oct 17;238(16):1750-3.


The removal of phenytoin by hemodialysis was determined in seven uremic patients. Four patients were receiving phenytoin sodium for therapeutic purposes; three received one dose each intravenously to quantitate its disposition in uremia. The drug was measured in whole blood, plasma, saliva, and dialysate. Only 2% to 4% of the intravenous dose was recovered in the dialysate. Phenytoin clearance by dialysis was 7 to 14 ml/min; plasma clearance was 53 to 133 ml/min. Since hemodialysis contributes little toward shortening to 11-to-18-hour half-life of phenytoin in the uremic patients, no supplemental dose is necessary for uremic patients undergoing hemodialysis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Epilepsy / prevention & control
  • Female
  • Half-Life
  • Humans
  • Male
  • Middle Aged
  • Phenytoin* / blood
  • Phenytoin* / metabolism
  • Phenytoin* / therapeutic use
  • Plasma / analysis
  • Renal Dialysis*
  • Saliva / analysis
  • Solutions
  • Uremia / complications*


  • Solutions
  • Phenytoin