Comparison of the effects of water deprivation and sodium chloride imbibition on the hormone content of the neurohypophysis of the rat

J Physiol. 1969 Aug;203(2):449-58. doi: 10.1113/jphysiol.1969.sp008874.

Abstract

1. Vasopressin and oxytocin have been measured in the neurohypophysis of rats which had either been given a 2% (w/v) NaCl solution to drink or been deprived of drinking water for up to 5 days.2. There was a progressive decrease in the vasopressin content of the glands in both groups; the rates of depletion were not significantly different.3. Oxytocin also decreased progressively in both groups but the glands from the ;saline-treated' rats contained less hormone than those from the ;water-deprived' animals.4. The differences in gland content of oxytocin could not be correlated with differences between the plasma osmolalities or sodium concentrations of the two groups.

MeSH terms

  • Animals
  • Hematocrit
  • Male
  • Osmolar Concentration
  • Oxytocin / analysis*
  • Pituitary Gland, Posterior / analysis*
  • Rats
  • Sodium / blood
  • Sodium Chloride / pharmacology*
  • Tissue Extracts
  • Vasopressins / analysis*
  • Water Deprivation*

Substances

  • Tissue Extracts
  • Vasopressins
  • Sodium Chloride
  • Oxytocin
  • Sodium