Guanylhydrazones with potential antileukemic activity. 2. Synthesis and structure-activity relationships of analogues of 4,4'-diacetyl-N,N'-diphenylurea bis(guanylhydrazone)

J Med Chem. 1978 Jun;21(6):507-13. doi: 10.1021/jm00204a002.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / metabolism
  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Carbanilides / analogs & derivatives
  • Carbanilides / chemical synthesis*
  • Carbanilides / pharmacology
  • Carbanilides / therapeutic use
  • Cells, Cultured
  • DNA-Directed DNA Polymerase / metabolism
  • Female
  • Leukemia L1210 / drug therapy
  • Leukemia L1210 / enzymology
  • Magnetic Resonance Spectroscopy
  • Mammary Neoplasms, Experimental / metabolism
  • Mice
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Carbanilides
  • DNA-Directed DNA Polymerase