Allergenic component of a liverwort: a sesquiterpene lactone

Science. 1969 Oct 10;166(3902):239-40. doi: 10.1126/science.166.3902.239.


Frullania spp. (Hepaticae, Jungermanniales) are agents of allergies. Extraction and fractionation of Frullania tamarisci has given, as the only allergenic component isolated, a levorotatory crystalline sutbstance, the structure of which is demonstrated. It is a sesquiterpene lactone. The racemic (+/-) form is isolated from a mixed sample of Frullania tamarisci and Frullania dilatata; the dextrorotatory form, from Frullania dilatata. The observed allergenic properties are shared by some other-sesquiterpene lactones.

MeSH terms

  • Chromatography, Gel
  • Dermatitis, Contact / chemically induced*
  • Humans
  • Lactones / isolation & purification*
  • Lactones / toxicity
  • Magnetic Resonance Spectroscopy
  • Plant Extracts / toxicity
  • Plants*
  • Stereoisomerism
  • Terpenes / isolation & purification*
  • Terpenes / toxicity


  • Lactones
  • Plant Extracts
  • Terpenes