Viral antibodies in diabetes mellitus

Br Med J. 1969 Sep 13;3(5671):627-30. doi: 10.1136/bmj.3.5671.627.


Sera from 123 patients with diabetes mellitus of recent onset, 155 patients with diabetes of more than two years' duration, and 250 normal persons were collected over a period of two and a half years. All sera were tested for neutralizing antibody to Coxsackie virus types B1-6, and a sample was tested for complement-fixing antibody to a number of viral, rickettsial, and mycoplasmal antigens.In diabetics of recent onset no evidence was found of any excess of antibodies to mumps virus or some common respiratory viruses. Insulin-dependent diabetes within three months of onset were found to have higher antibody titres to Coxsackie B virus, particularly of type B4, than either normal subjects or patients with diabetes of longer duration.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies*
  • Antigens
  • Child
  • Child, Preschool
  • Complement Fixation Tests
  • Diabetes Mellitus / immunology*
  • Enterovirus / immunology*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Mycoplasma / immunology
  • Neutralization Tests
  • Rickettsia / immunology


  • Antibodies
  • Antigens