Transplantation of pluripotential nuclei from triploid frog tumors

Science. 1969 Jul 25;165(3891):394-6. doi: 10.1126/science.165.3891.394.


Renal tumors were produced by injection of a cell fraction of a tumor into triploid tadpoles of Rana pipiens before they began feeding. Triploid tumor cells were dissociated and transplanted into activated and enucleated eggs. Pluripotency of the implanted nuclei was evidenced by the formation of swimming triploid tadpoles.

MeSH terms

  • Animals
  • Anura
  • Female
  • Kidney Neoplasms / pathology*
  • Metamorphosis, Biological
  • Neoplasm Transplantation*
  • Neoplasms, Experimental / pathology*
  • Nuclear Transfer Techniques*
  • Ovum
  • Polyploidy*
  • Regeneration