The failure of conventional drug therapy in the management of infantile colic

Am J Dis Child. 1979 Oct;133(10):999-1001. doi: 10.1001/archpedi.1979.02130100023003.


During five years, 97 young infants with colic were studied. One of us (J. C. O'D.) compared homatropine methylbromide plus phenobarbital in a 20% alcohol solution, and all of the individual components of that solution, to see which was most effective in the symptomatic relief of colic. Regardless of the child's age on entry into the study, conditions in no treatment group improved more rapidly than in those treated with a placebo.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Colic / drug therapy*
  • Double-Blind Method
  • Drug Therapy, Combination
  • Ethanol / therapeutic use*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Phenobarbital / therapeutic use*
  • Placebos
  • Tropanes / therapeutic use*


  • Placebos
  • Tropanes
  • Ethanol
  • Phenobarbital