[Chromatographic separation of racemic thalidomide and teratogenic activity of its enantiomers (author's transl)]

Arzneimittelforschung. 1979;29(10):1640-2.
[Article in German]

Abstract

Racemic thalidomide is chromatographically separated on optically active polyamide giving both enantiomers. After i.p. administration only the S-(-)-enantiomer is teratogenic on SWS mice and Natal rats.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Chromatography
  • Embryo, Mammalian / drug effects
  • Female
  • Lethal Dose 50
  • Mice
  • Mice, Inbred ICR
  • Pregnancy
  • Rats
  • Stereoisomerism
  • Teratogens
  • Thalidomide / isolation & purification*
  • Thalidomide / toxicity

Substances

  • Teratogens
  • Thalidomide