Effect of lidocaine on the absorption, disposition and tolerance of intramuscularly administered cefoxitin

Eur J Clin Pharmacol. 1977 Dec 2;12(4):273-9. doi: 10.1007/BF00607426.


The use of lidocaine HCL solution at concentrations of 0.5 and 1.0% to reconstitute sodium cefoxitin relieves the pain associated with intramuscular injections of the antibiotic. Cefoxitin absorption by the intramuscular route is initially rapid and is virtually complete. Peak serum concentrations, corresponding to about one-half those of a comparable intravenous infusion, are achieved in 30 min. Continuing absorption tends to maintain higher serum concentrations for longer times. Renal clearance and serum half-life of cefoxitin do not appear to be affected by lidocaine at its effective anaesthetic concentrations.

MeSH terms

  • Absorption
  • Adult
  • Cefoxitin / administration & dosage
  • Cefoxitin / adverse effects
  • Cefoxitin / metabolism*
  • Cephalosporins / metabolism*
  • Drug Interactions
  • Half-Life
  • Humans
  • Injections, Intramuscular
  • Kinetics
  • Lidocaine / pharmacology*
  • Male
  • Time Factors


  • Cephalosporins
  • Cefoxitin
  • Lidocaine