Antibody formation in nonimmune mouse peritoneal cells after incubation in gum containing antigen

Science. 1966 Aug 19;153(3738):887-8. doi: 10.1126/science.153.3738.887.

Abstract

Peritoneal cells from normal mice in a semisolid medium containing sheep erythrocytes were incubated at 37 degrees C for 2 or 3 days. During this period, hemolytic antibodies developed spontaneously. Arguments are presented that true de novo synthesis of antibody has taken place in previously uncommitted cells.

MeSH terms

  • Animals
  • Antibody Formation*
  • Erythrocytes*
  • In Vitro Techniques
  • Lymph Nodes
  • Methylcellulose
  • Mice
  • Peritoneum*
  • Rabbits
  • Resins, Plant*
  • Sheep
  • Spleen

Substances

  • Resins, Plant
  • Methylcellulose