Sleep deprivation and brain acetylcholine

Science. 1966 Sep 16;153(3742):1416-7. doi: 10.1126/science.153.3742.1416.


Rats deprived of D-state sleep (and, to some extent, of slow-wave sleep) for 96 hours show a significant fall in brain acetylcholine in the telencephalon; there were no significant changes in the diencephalon and brain stem. Restraint stress and activity wheel stress produced no significant change in acetylcholine levels in any of these regions; the telencephalic response to sleep deprivation, therefore, cannot be attributed to nonspecific stress. The effects of D-state deprivation and the psychoactive anticholinergic drugs on telencephalic acetylcholine levels are similar.

MeSH terms

  • Acetylcholine / metabolism*
  • Animals
  • Brain Chemistry*
  • Male
  • Rats
  • Sleep*
  • Stress, Physiological*
  • Telencephalon / metabolism*


  • Acetylcholine