Separation of membrane currents using a Paramecium mutant

Nature. 1977 Jul 14;268(5616):120-4. doi: 10.1038/268120a0.

Abstract

The net membrane current of the electrically excitable membrane of Paramecium during step depolarisations was measured using voltage-clamp techniques. The mutant, pawn B, lacks a functional Ca channel. Thus the difference between the total current measured in the wild type and the leakage and rectification currents measured in the pawn mutant is the Ca current. These findings were confirmed by ion substitution experiments. The possibility that inactivation may be apparent only, and caused by a hypothetical, superposed, Ca-induced, rectifying K+ current was eliminated.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Calcium / physiology
  • Cell Membrane / physiology
  • Cilia / physiology
  • Electric Conductivity
  • Electrophysiology
  • Membrane Potentials
  • Mutation
  • Paramecium / physiology*
  • Potassium / physiology

Substances

  • Potassium
  • Calcium