Evolution of ageing

Nature. 1977 Nov 24;270(5635):301-4. doi: 10.1038/270301a0.


An evolutionary view of ageing suggests that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells. This supports Orgel's 'error catastrophe' hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell lines.

MeSH terms

  • Aging*
  • Animals
  • Biological Evolution*
  • Cell Survival
  • Cell Transformation, Neoplastic
  • Fibroblasts / physiology
  • Humans
  • Metabolism
  • Models, Biological
  • Protein Biosynthesis