Human chorionic gonadotropin (HCG) in the treatment of obesity: a critical assessment of the Simeons method

West J Med. 1977 Dec;127(6):461-3.


Injections of human chorionic gonadotropin (HCG) have been claimed to aid in weight reduction by reducing hunger, and affecting mood as well as aiding in localized (spot) reduction. We have tested these claims in a double-blind randomized trial using injections of HCG or placebo. Weight loss was identical between the two groups, and there was no evidence for differential effects on hunger, mood or localized body measurements. Placebo injections, therefore, appear to be as effective as HCG in the treatment of obesity.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Chorionic Gonadotropin / therapeutic use*
  • Diet, Reducing
  • Double-Blind Method
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Obesity / diet therapy
  • Obesity / drug therapy*


  • Chorionic Gonadotropin