Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

J Pharmacokinet Biopharm. 1977 Dec;5(6):625-53. doi: 10.1007/BF01059688.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Cells / metabolism
  • Humans
  • Liver / enzymology
  • Liver / metabolism*
  • Liver Circulation
  • Models, Biological
  • Pharmaceutical Preparations / blood
  • Pharmaceutical Preparations / metabolism*


  • Pharmaceutical Preparations