Hepatic clearance of drugs. III. Additional experimental evidence supporting the "well-stirred" model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liver in situ preparation

J Pharmacokinet Biopharm. 1977 Dec;5(6):681-99. doi: 10.1007/BF01059690.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • In Vitro Techniques
  • Lidocaine / metabolism*
  • Liver / metabolism*
  • Liver Circulation
  • Models, Biological
  • Perfusion
  • Rats


  • Lidocaine