Complementation between mutants of CHO cells resistant to a variety of plant lectins

Somatic Cell Genet. 1977 Jul;3(4):391-405. doi: 10.1007/BF01542968.


Chinese hamster cell mutants resistant to the lectins PHA, WGA, RIC, LCA, and CON A were previously grouped into 8--10 distinct phenotypes on the basis of their unique patterns of lectin resistance and lectin-binding properties. All but one of these classes of lectin-resistant (LecR) mutants behave recessively in somatic cell hybrids. One ricin-resistant class (RicRII) behaves dominantly. Tests for complementation, by measuring the lectin-resistant properties of appropriate hybrids, show that seven distinct complimentation groups can be delineated among the phenotypically recessive mutants.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Concanavalin A / pharmacology
  • Drug Resistance*
  • Genes*
  • Genetic Complementation Test
  • Hybrid Cells
  • Lectins / pharmacology*
  • Mutation
  • Phenotype


  • Lectins
  • Concanavalin A