Oxidative phosphorylation in experimental bilirubin encephalopathy

Science. 1967 Mar 10;155(3767):1288-9. doi: 10.1126/science.155.3767.1288.

Abstract

Mitochondria from the whole brain or cerebellum of newborn guinea pigs with experimental bilirubin encephalopathy failed to exhibit uncoupling of oxidative phosphorylation. The pigment concentrations required to initiate uncoupling in vitro are much higher than those found in the brain of neurotoxic animals.

MeSH terms

  • Animals
  • Bilirubin / pharmacology*
  • Brain Diseases / chemically induced*
  • Carbon Isotopes
  • Cerebellum / metabolism
  • Guinea Pigs
  • Hyperbilirubinemia / chemically induced*
  • Microscopy, Electron
  • Mitochondria / drug effects*
  • Mitochondria / metabolism*
  • Oxidative Phosphorylation / drug effects*
  • Oxygen Consumption
  • Spectrophotometry

Substances

  • Carbon Isotopes
  • Bilirubin