Human sleep and 5-HTP. Effects of repeated high doses and of association with benserazide (RO.04.4602)

Electroencephalogr Clin Neurophysiol. 1976 Oct;41(4):408-13. doi: 10.1016/0013-4694(76)90103-6.


On account of the conflicting data concerning the action of 5-HTP on human sleep, repeated high doses were administered to three healthy subjects. The paradoxical sleep time and percentage tend to show a decrease during the 2nd week of treatment, followed by a rebound effect after the end of the treatment. In two subjects who initially had a small amount of slow wave sleep (SWS), the treatment induced an increase in SWS that persisted after the end of the treatment. Similar results were obtained after administration of 5-HTP together with RO.04.4602.

MeSH terms

  • 5-Hydroxytryptophan / administration & dosage
  • 5-Hydroxytryptophan / pharmacology*
  • Adult
  • Benserazide / administration & dosage
  • Benserazide / pharmacology*
  • Drug Combinations
  • Electroencephalography
  • Humans
  • Hydrazines / pharmacology*
  • Male
  • Mental Processes / drug effects
  • Sleep Stages / drug effects*


  • Drug Combinations
  • Hydrazines
  • Benserazide
  • 5-Hydroxytryptophan