Sodium transport: inhibitory factor in sweat of patients with cystic fibrosis

Science. 1967 Oct 6;158(3797):135-6. doi: 10.1126/science.158.3797.135.


A factor inhibitory to sodium transport exists in the sweat of patients with cystic fibrosis of the pancreas. When the duct system of the rat parotid was perfused with sweat from patients, marked inhibition of sodium reabsorption was observed. Perfusion with sweat from normal subjects caused no change in sodium reabsorption. The factor thus demonstrated may be responsible for the increased sodium concentrations in the sweat of patients with cystic fibrosis.

MeSH terms

  • Absorption
  • Animals
  • Antimetabolites / metabolism
  • Antimetabolites / physiology*
  • Biological Transport, Active*
  • Cystic Fibrosis / metabolism*
  • Humans
  • Parotid Gland / physiology
  • Perfusion
  • Pilocarpine / pharmacology
  • Rats
  • Salivation
  • Sodium / metabolism*
  • Sweat Glands / metabolism
  • Sweat Glands / physiopathology*
  • Sweat*


  • Antimetabolites
  • Pilocarpine
  • Sodium