Effect of low-dose subcutaneous heparin on whole-blood viscosity

Lancet. 1976 Aug 14;2(7981):342-4. doi: 10.1016/s0140-6736(76)92595-2.


The change in blood-viscosity at low shear-rates (0.77 s-1 and 2-62 s-1 was measured in eighteen normal subjects and postoperatively in sixteen patients after administration of 5000 I.U. of subcutaneous heparin. In both groups there was a significant decrease in the mean blood-viscosity 4 to 6 hours after the injection of heparin. This fall in blood-viscosity may be involved in the prophylactic effect of low-dose subcutaneous heparin in preventing venous thrombosis.

MeSH terms

  • Blood Viscosity / drug effects*
  • Heparin / administration & dosage
  • Heparin / pharmacology*
  • Heparin / therapeutic use
  • Humans
  • Injections, Subcutaneous
  • Postoperative Complications / prevention & control
  • Thrombophlebitis / prevention & control
  • Time Factors


  • Heparin