Uterotropic effect of beta-HCH, a food chain contaminant

Food Addit Contam. Jan-Mar 1984;1(1):63-6. doi: 10.1080/02652038409385824.

Abstract

The uterotropic effect of beta-HCH was assessed in juvenile female mice and rats. A dose of 50 mg/kg feed over five days gave a significant increase in the uterine weight. The potency of beta-HCH compared to 17 alpha-ethynyloestradiol was about 20 X 10(-6). Based on these and other as yet unpublished observations, it is concluded that beta-HCH has oestrogenic features.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Ethinyl Estradiol / pharmacology
  • Female
  • Hexachlorocyclohexane / administration & dosage
  • Hexachlorocyclohexane / pharmacology*
  • Mice
  • Organ Size / drug effects
  • Rats
  • Uterus / anatomy & histology*

Substances

  • Ethinyl Estradiol
  • Hexachlorocyclohexane
  • beta-hexachlorocyclohexane