Humoral factors in regulation of compensatory renal hypertrophy

Kidney Int. 1983 Apr;23(4):611-5. doi: 10.1038/ki.1983.66.

Abstract

Compensatory renal hypertrophy in transplanted kidneys shows that the major regulators are humoral. Crosscirculation experiments are confirmatory indicating further that the regulators are short-lived and must be consistently present during the early phases of hypertrophy. Controls are difficult to achieve in other systems; variables relate to nutrition, means of assay, pharmacokinetics, and abnormalities produced by the experimental model itself. A simple hypothesis to account for the events precipitating renal hypertrophy might integrate the onsets of renal hyperemia soon after contralateral nephrectomy with the activation of pre-existing stimulators specific for the kidney.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA / analysis
  • Growth Substances / physiology*
  • Hypertrophy
  • Intercellular Signaling Peptides and Proteins*
  • Kidney / pathology*
  • Kidney Transplantation
  • Mitotic Index
  • RNA / analysis
  • Renal Circulation

Substances

  • Growth Substances
  • Intercellular Signaling Peptides and Proteins
  • renotropins
  • RNA
  • DNA