Abstract
Marked reductions in opiate receptor binding (-42%), "enkephalinase" activity (-39%), and Met5-enkephalin levels (-72%) accompanied the well-established dopamine depletion in the substantia nigra pars compacta of Parkinsonian subjects. In contrast, enkephalinergic markers were not significantly modified in caudate nucleus.
MeSH terms
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Aged
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Caudate Nucleus / metabolism*
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Dopamine / metabolism
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Endopeptidases / metabolism*
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Enkephalin, Methionine / metabolism*
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Humans
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Neprilysin
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Organ Specificity
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Parkinson Disease / metabolism*
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Receptors, Opioid / metabolism*
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Reference Values
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Substantia Nigra / metabolism*
Substances
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Receptors, Opioid
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Enkephalin, Methionine
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Endopeptidases
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Neprilysin
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Dopamine