Enkephalinergic markers in substantia nigra and caudate nucleus from Parkinsonian subjects

J Neurochem. 1984 Sep;43(3):874-7. doi: 10.1111/j.1471-4159.1984.tb12812.x.

Abstract

Marked reductions in opiate receptor binding (-42%), "enkephalinase" activity (-39%), and Met5-enkephalin levels (-72%) accompanied the well-established dopamine depletion in the substantia nigra pars compacta of Parkinsonian subjects. In contrast, enkephalinergic markers were not significantly modified in caudate nucleus.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Caudate Nucleus / metabolism*
  • Dopamine / metabolism
  • Endopeptidases / metabolism*
  • Enkephalin, Methionine / metabolism*
  • Humans
  • Neprilysin
  • Organ Specificity
  • Parkinson Disease / metabolism*
  • Receptors, Opioid / metabolism*
  • Reference Values
  • Substantia Nigra / metabolism*

Substances

  • Receptors, Opioid
  • Enkephalin, Methionine
  • Endopeptidases
  • Neprilysin
  • Dopamine