Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

Nature. 1984 Oct;311(5985):433-8. doi: 10.1038/311433a0.


Transcription of the c-fos proto-oncogene is greatly increased within minutes of administering purified growth factors to quiescent 3T3 cells. This stimulation is the most rapid transcriptional response to peptide growth factors yet described, and implies a role for c-fos in cell-cycle control. Transformation by c-fos may result from a temporal deregulation of this control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Actins / metabolism
  • Animals
  • Cell Nucleus / physiology
  • Cell-Free System
  • Cytoplasm / metabolism
  • Gene Expression Regulation*
  • Growth Substances / pharmacology*
  • Mice
  • Oncogenes*
  • RNA, Messenger / genetics
  • Sarcoma Viruses, Murine / genetics
  • Transcription, Genetic*


  • Actins
  • Growth Substances
  • RNA, Messenger