Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

Nature. 1984 Oct 18-24;311(5987):626-31. doi: 10.1038/311626a0.

Abstract

We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNAs which differ in their polyadenylation signals. We have isolated an additional cDNA that may correspond to an alternatively spliced mRNA that lacks a 216 base segment and appears to encode an altered membrane protein which cannot bind interleukin-2.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular*
  • DNA / metabolism*
  • Deltaretrovirus / genetics
  • Genes*
  • Genes, Viral
  • Humans
  • Nucleic Acid Hybridization
  • Protein Biosynthesis
  • RNA, Messenger / genetics
  • Receptors, Antigen, T-Cell / genetics*
  • Receptors, Immunologic / genetics*
  • Receptors, Immunologic / isolation & purification
  • Receptors, Interleukin-2

Substances

  • RNA, Messenger
  • Receptors, Antigen, T-Cell
  • Receptors, Immunologic
  • Receptors, Interleukin-2
  • DNA

Associated data

  • GENBANK/K03122
  • GENBANK/X01057
  • GENBANK/X01058
  • GENBANK/X01402