Specific IgE antibodies in twenty-eight workers with diisocyanate-induced bronchial asthma

Clin Allergy. 1984 Sep;14(5):453-61. doi: 10.1111/j.1365-2222.1984.tb02229.x.


A specific IgE-mediated response was evaluated in twenty-eight workers exposed to TDI or MDI, with diagnosis of occupational asthma and positive to bronchial provocative challenge. The presence of anti-diisocyanate IgE was observed in 27% of subjects exposed to TDI and 83% of those exposed to MDI, particularly in individuals who experienced an acute massive exposure. An immediate-type response to bronchial provocative test was found in 66% of individuals with specific antibodies. Specific IgE are prevalent (91%) in subjects who developed symptoms before 6 years of exposure to isocyanates. The results suggest an association between the presence of specific IgE, early asthmatic symptoms and heavy episodic exposure.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asthma / immunology*
  • Bronchial Provocation Tests
  • Cyanates / adverse effects*
  • Cyanates / immunology
  • Female
  • Humans
  • Hypersensitivity, Immediate
  • Immunoglobulin E / analysis*
  • Isocyanates*
  • Male
  • Occupational Diseases / immunology*
  • Toluene 2,4-Diisocyanate / adverse effects*
  • Toluene 2,4-Diisocyanate / immunology


  • Cyanates
  • Isocyanates
  • Toluene 2,4-Diisocyanate
  • Immunoglobulin E
  • 2,6-diisocyanatotoluene
  • 4,4'-diphenylmethane diisocyanate